The length of the shortest telomere as the major determinant of the onset of replicative 1 senescence 2
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چکیده
The length of the shortest telomere as the major determinant of the onset of replicative 1 senescence 2 3 Zhou Xu, Khanh Dao Duc, David Holcman, Maria Teresa Teixeira 4 5 6 Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Institut de Biologie 7 Physico-Chimique, Centre National de la Recherche Scientifique, Université Pierre et Marie 8 Curie, FRE3354, 75005 Paris, France 9 Institute for Biology (IBENS), Group of Computational Biology and Applied Mathematics, 10 École Normale Supérieure de Paris, 75005 Paris, France 11 12 13 Genetics: Early Online, published on June 3, 2013 as 10.1534/genetics.113.152322
منابع مشابه
The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence
The absence of telomerase in many eukaryotes leads to the gradual shortening of telomeres, causing replicative senescence. In humans, this proliferation barrier constitutes a tumor suppressor mechanism and may be involved in cellular aging. Yet the heterogeneity of the senescence phenotype has hindered the understanding of its onset. Here we investigated the regulation of telomere length and it...
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تاریخ انتشار 2013